Functional Neurological Disorder in the Context of Persisting Symptoms after Concussion

Time to Shift Our Perspective?

Presenters: Dr. Evan Lewis, MD | Jenni Diamond, OT Reg. (Ont.)

📄 Poster & Presentation Files

🧠 Key Concepts & Visuals

This framework builds on established understanding of concussion pathophysiology, showing how Functional Neurological Disorder (FND) may emerge through persistent brain network dysfunction in predisposed individuals following concussion.

  • Neurometabolic cascade and cellular disruption post-concussion
  • Maladaptive network reconfiguration as the core mechanism for FND emergence
  • Overlap in brain network dysfunction patterns in PSaC and FND

Figures coming soon.

🎥 Video Resources

📘 Educational & Learning Resources

📚 References

  1. Giza, C. C., & Hovda, D. A. (2014). The new neurometabolic cascade of concussion. Neurosurgery, 75(Suppl 4), S24–S33.
  2. Baertschi, M., et al. (2023). Biopsychosocial complexity in patients with FND. BMJ Neurology Open, 5(1), e000337.
  3. Kenzie, E. S., et al. (2017). Concussion as a multi-scale complex system. Front Neurol, 8:513.
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  7. Kaushal, M., et al. (2019). Functional connectivity after concussion. Hum Brain Mapp, 40(4):1211–1220.
  8. Mavroudis, I., et al. (2023). Functional Overlay Model of Persistent Post-Concussion Syndrome. Brain Sci, 13(7):1028.
  9. Shafi, R., et al. (2020). Sex-specific RSFC in post-concussion syndrome. Sci Rep, 10:21982.
  10. Gumus, M., et al. (2022). Brain connectivity changes in PCS. Brain Connect, 12(8):711–724.
  11. Clark, C. N., et al. (2022). Reframing postconcussional syndrome. Brain, 145(6):1906–1915.
  12. Jobin, K., et al. (2023). Screening for FND in persistent PCS. NeuroRehabilitation, 53(2):199–208.
  13. Griffith, O., et al. (2024). Comorbidity of concussion and depression. Brain Res, 1845:149200.

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